It is responsible for converting glucose to energy. Objectives: For example, it may help with appetite control. Alpha-lipoic acid has been used in alternative medicine as a possibly effective aid in weight loss, treating diabetic nerve pain, healing wounds, lowering blood sugar, improving skin discoloration caused by vitiligo, and decreasing complications of coronary artery bypass graft (CABG) surgery. Alpha-lipoic acid or ALA is a naturally occurring compound that's made in the body. . Keywords: Alpha Lipoic Acid is hydrophilic and lipophilic (amphipathic), which allows it to reach every part of cells, including the mitochondria. Watanabe M, Risi R, Masi D, Caputi A, Balena A, Rossini G, Tuccinardi D, Mariani S, Basciani S, Manfrini S, Gnessi L, Lubrano C. Nutrients. Results: A study published in the "American Journal of Medicine" in 2011, showed that obese people who took 1,800 mg of alpha-lipoic acid per day lost significantly more weight than people who used a placebo product. Privacy Policy The purpose of this study is to conduct a meta-analysis of the effect of ALA on weight and body mass index (BMI). Let us see how it is connected to thyroid health and its effectiveness as a weight loss aid. Results: Body weight loss was significantly higher (P<0.05) in those groups supplemented with α-lipoic acid. used as a substitute for professional medical advice, Flow Chart Depicting Selection of…, Figure 1. Alpha-lipoic acid (ALA) is a naturally occurring antioxidant. Much of the research involving alpha-lipoic acid has been centered on the prevention of diabetes and the management of diabetic nerve pain. Weight Loss. any of the products or services that are advertised on the web site. See this image and copyright information in PMC. Always talk to your doctor before beginning to take dietary supplements. Obesity is a serious health condition that has been increasing considerably since the 1980s in the United States. Flow Chart Depicting Selection of Studies, Figure 2. How Alpha Lipoic Acid Influences Weight & Helps with Weight Loss The weight loss effects of ALA are likely due to multiple different factors. A new study conducted in Spain indicates that the dietary supplement alpha-lipoic acid (ALA) is both a safe and effective adjunct to calorie reduction in promoting weight loss. The second trial, this time from Korea, looked at the effect of two different doses of racemic alpha-lipoic acid on weight loss in a group of 360 overweight and obese men and women. Leaf Group Ltd. Another study published in "Current Pharmaceutical Design" in 2010, showed that a dose of 800 mg per day for four months cause a weight loss between 8 and 9 nine percent of body weight in obese or pre-obese teens. Alpha-lipoic acid is an antioxidant and an essential co-factor needed for mitochondrial function. Terms of Use New Data on Alpha Lipoic Acid. Study duration significantly affected BMI change, but not weight change. The Effect of 600 mg Alpha-lipoic Acid Supplementation on Oxidative Stress, Inflammation, and RAGE in Older Adults with Type 2 Diabetes Mellitus. 2020 Sep 1;150(9):2336-2345. doi: 10.1093/jn/nxaa203. Alpha-lipoic acid; body mass; diabetes; thioctic acid. Alpha-lipoic acid supplementation significantly reduces the risk of obesity in an updated systematic review and dose response meta-analysis of randomised placebo-controlled clinical trials. Despite the positive research results, alpha-lipoic acid is not a miracle pill that will make you lose weight on its own. Okanovic, A., Prnjavorac, B., Jusufovic, E., & Sejdinovic, R. (2015, July 9). eCollection 2019. Alpha lipoic acid (ALA) is a highly-potent antioxidant that is available as a dietary supplement. EPA supplementation significantly attenuated (P<0.001) the decrease in leptin levels that occurs during weight loss. Bobe G, Michels AJ, Zhang WJ, Purnell JQ, Woffendin C, Pereira C, Vita JA, Thomas NO, Traber MG, Frei B, Hagen TM. Using Alpha Lipoic acid to address the weight issue in hypothyroidism is a tried and tested method. A significant overall mean BMI difference of -0.43 kg/ m 2 (confidence interval = -0.82 to … It serves vital functions at the cellular level, such as energy production. 2012 Oct;167(4):465-71. doi: 10.1530/EJE-12-0555. And if you want to add EPA, I recommend taking it in the form of fish oil so that you get a dose of the essential fatty acid DHA at the same time. It’s located in the hypothalamus in the brain and in high levels, it increases hunger. Please enable it to take advantage of the complete set of features! Research has shown that alpha-lipoic acid may affect weight loss in several ways.. Use of this web site constitutes acceptance of the LIVESTRONG.COM The various drugs used to promote weight loss, as well as many dietary supplements for the same, are fraught with both efficacy and safety issues. more than the group who were asked to take a placebo. Despite that fact, there has been a lot of recent interest in using ALA supplements. HHS Epub 2020 Mar 26. Int J Clin Pract. Alpha-lipoic acid can help you lose weight according to scientific research. Source: 1 “Effects of α-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss.” Obesity (Silver Spring). Alpha-lipoic acid’s ability to enhance calorie burning and promote weight loss has been exaggerated by many diet gurus and supplements manufacturers. “The effect of lipoic acid supplements on blood lipids was limited,” said Gerd Bobe, another LPI scientist who collaborated on the study. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: doi: 10.1111/ijcp.13493. Antioxidants such as alpha lipoic acid can help neutralize and protect your body from those excess free radicals. The supplement speeded up weight loss, as the figure below shows. Lipids, 49(12), 1193-201. (More information) 3. She graduated with a bachelor‚Äôs degree in laboratory sciences from Helsinki Polytechnic in 2002 and is currently working on her doctoral degree in cell and molecular biology. (iv.111)However, currently there is considerable disagreement amongst researchers about the benefits of using antioxidant supplements with an exercise program. Alpha lipoic Acid (ALA) ALA is a naturally formed substance made in every cell of our body. R01 DK093924/DK/NIDDK NIH HHS/United States. Obesity is a serious health condition that has been increasing considerably since the 1980s in the United States. The participants were assigned to one of three groups. Using alpha lipoic acid for weight loss is recommended as part of a balanced diet and adequate physical fitness regimen. Alpha-lipoic acid has also been researched as a treatment for many other conditions. Further research is needed to examine the effect of different doses and the long-term benefits of ALA on weight management. Alpha-lipoic acid does not generally cause serious side effects, according to a study published in "American Journal of Medicine". These weight loss pills send 20% more glucose to away from fat cells and into muscle cells - which helps with weight loss and building muscle as more energy is used during exercise and less stored away as fat. Doctor’s Best Alpha-Lipoic Acid (600 mg): This is a high-dose alpha-lipoic acid supplement that sells for around $0.16 per capsule. As long as you're healthy, the body can produce all the ALA it needs for these purposes. The LIVESTRONG Foundation and LIVESTRONG.COM do not endorse , ; 2010, PARTNER & LICENSEE OF THE LIVESTRONG FOUNDATION. The number of Alpha Lipoic Acid ability as an antioxidant, making Alpha Lipoic Acid is considered as a potent antioxidant. Front Physiol. eCollection 2020. Clipboard, Search History, and several other advanced features are temporarily unavailable. 2020 Sep 30;29(3):163-165. doi: 10.7570/jomes20070. doi: 10.2337/diab.46.2.s62. Clin Nutr. Moreover, we do not select every advertiser or advertisement that appears on the web site-many of the Copyright Policy Obesity is associated with significant morbidity and mortality rates. Alpha-lipoic acid supplementation reduces mTORC1 signalling in skeletal muscle from high fat fed, obese Zucker rats. Before using alpha-lipoic acid for weight loss, talk to a medical doctor to ensure that it is safe (based on your medical status and medication or supplement regimen). These include Amanita mushroom poisoning, glaucoma , kidney disease , migraines , and peripheral arterial disease. The weight-loss enhancing ability of alpha lipoic acid has been put to the test in human studies as well.  |  After participants took 600 mg of the lipoic acid for a period of 24 weeks, “The data clearly showed a loss in body weight and body fat in people taking lipoic acid supplements,” said Balz Frei, director emeritus of OSU’s Linus Pauling Institute and one of the scientists on the study. 2018 Apr;37(2):419-428. doi: 10.1016/j.clnu.2017.06.002. 2020 Jun;74(6):e13493. Advocates of ALA make claims that range from beneficial effects for treating conditions such as diabetes and HIV to enhancing weight loss. diagnosis or treatment. The material appearing on LIVESTRONG.COM is for educational use only. ; 2011, Current Pharmaceutical Design; Alpha-lipoic Acid Supplementation: A Tool for Obesity Therapy; M.G. Alpha-lipoic acid treatment coincided with a statistically significant 1.27 kg (confidence interval = 0.25 to 2.29) greater mean weight loss compared with the placebo group. Methods: Get the latest public health information from CDC: With that being said, there is growing evidence that alpha-lipoic acid can influence weight, albeit modestly. Epub 2017 Feb 26. The antioxidant works by stimulating the body's ability to convert food into energy and is water soluble. Mean BMI differences between ALA…, Figure 3. To further clarify earlier ALA findings, researchers launched a 10-week study. Alpha lipoic acid (ALA) is a fatty acid that occurs naturally in the body and serves vital functions at the cellular level, such as energy production. Supplementation with lipoic acid transiently increases plasma and cellular concentratio… In supplement form, it has long been taken to improve glucose sensitivity and treat diabetes, but more recently attention has moved to its potential for weight loss … Studies have noticed that it may reduce enzyme AMP-activated protein kinase (AMPK) activity. Group one took 1200 milligrams of alpha-lipoic acid per day (ALA-1200). Oxid Med Cell Longev. In addition to neutralizing free radicals, Alpha Lipoic Acid can also bind to and disable heavy metals such as iron-free (free iron), cadmium, magnesium, copper, mercury, zinc, nickel, cobalt, arsenic, manganese and lead. Understanding the Associations between Dietary Antioxidants and Obesity. Copyright © Alpha-Lipoic Acid: Weight Loss, Other Benefits and Side Effects Written by Ryan Raman, MS, RD Alpha-lipoic acid is an organic compound that acts as a powerful antioxidant in your body. 2019 Jun 12;2019:3276958. doi: 10.1155/2019/3276958. A systematic review of 12 clinical trials shows study participants supplementing with alpha-lipoic acid lost, on average, 1.52 pounds (0.69 kg) more than the placebo group. Leptin has also garnered quite a bit of interest in the field of weight loss studies. ALA has been used in supplement form to help in the treatment of diabetes, HIV, cancer, liver ailments, and has recently gained more popularity in the use of weight loss. Epub 2012 Jul 25. I've been using it for years in my practice. Studies of alpha-lipoic acid examined its properties as a supplement to reduce the risk of cardiovascular disease and as a possible supplement for weight loss. Potential conflicts of interest: Authors report no competing interests, Figure 1. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. However, before using any supplements for your diet you should consult with your doctor first. Some reported side effects included allergic skin reactions, itching, abdominal pain, nausea, vomiting and diarrhea. COVID-19 is an emerging, rapidly evolving situation. Diabetes. Results: Alpha-lipoic acid treatment coincided with a statistically significant 1.27 kg (confidence interval = 0.25 to 2.29) greater mean weight loss compared with the placebo group. J Obes Metab Syndr. (More information) 2. But the studies done on humans have shown that the alpha lipoic acid weight loss has only small effects. Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases. This site needs JavaScript to work properly. Alpha-lipoic acid reacts with oxygen radicals that protect cell membranes, protect against LDL oxidation and modulation of hypertension. Get the latest research from NIH: Mendoza-Núñez VM, García-Martínez BI, Rosado-Pérez J, Santiago-Osorio E, Pedraza-Chaverri J, Hernández-Abad VJ. If you're vigorously exercising to shed pounds you're burning more oxygen — which creates more free radicals. Studies have suggested anti-obesity properties of ALA; however, results are inconsistent. Alpha-lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy. Body weight loss improved lipid and glucose metabolism parameters but without significant differences between groups. 12 studies were analyzed and it was discovered that those who are taking the alpha-lipoic acid 300 mg supplements have lost an average of 1.52 lbs. Meta-regression analysis showed no significance in ALA dose on BMI and weight changes. 2017 May;86(5):680-687. doi: 10.1111/cen.13303. 2020 Sep 20;12(9):2873. doi: 10.3390/nu12092873. ; 2003, American Journal of Medicine; Effects of Alpha-lipoic Acid on Body Weight..; E.H. Koh, et al. A comprehensive, systematic literature search identified 10 articles on randomized, double-blind, placebo-controlled studies involving ALA. We conducted a meta-analysis of mean weight and BMI change differences between ALA and placebo treatment groups. Effects of oral α-lipoic acid administration on body weight in overweight or obese subjects: a crossover randomized, double-blind, placebo-controlled trial. Alpha-lipoic acid treatment showed small, yet significant short-term weight loss compared with placebo. Maria Parepalo began writing professionally in 2006 and has published in medical journals as well as online. In the weight-loss studies alpha-lipoic acid supplementation combined with a low calorie diet. Mean body weight differences between ALA treatment and placebo, Figure 3. What is Alpha Lipoic Acid? and Studies indicate that alpha-lipoic acid may help you lose weight but they admit more research is needed and you might not have similar results with the supplementation as subjects in the study. LIVESTRONG is a registered trademark of the LIVESTRONG Foundation. It should not be Time will only tell what added benefits researchers will track down proving the positive help alpha lipoic acid gives individuals around the world. Animal studies suggest that weight loss through alpha-lipoic acid is gained at the cost of lean body mass, but that was not the case in … Even modest weight loss may be associated with health benefits. A systematic review and meta-analysis of α-lipoic acid in the treatment of diabetic peripheral neuropathy. Li N, Yan W, Hu X, Huang Y, Wang F, Zhang W, Wang Q, Wang X, Sun K. Clin Endocrinol (Oxf). I typically recommend 3,000 mg EPA and DHA per day.  |  advertisements are served by third party advertising companies. I had ben having electrical like tingling in lower legs … Alpha Lipoic Acid can also aid in the breakdown of carbohydrates in the body - … may earn compensation through affiliate links in this story. J Nutr. Eur J Endocrinol. Centers for Disease Control and Prevention: Obesity, Journal of Nutrition; Alpha-lipoic Acid and Cardiovascular Disease; Stephanie Wollin, et al. This added substance is giving individuals a boost when they need it the most, from something that is made within the human body already. Alpha-lipoic acid reduces body weight and regulates … In the group that took 1800 mg alpha-lipoic acid per day the effect was statistically significant. When united with a healthy diet and regular exercise, alpha-lipoic acid can help you lose more weight than without the supplementation. Alpha Lipoic Acid is a strong antioxidant that boosts the strength of vitamins C and E, and helps aid in the body’s energy production. Alpha-lipoic acid may help you reduce weight. “But people who lost weight on lipoic acid also reduced their blood triglyceride levels – that effect was clear.” Other effects of the lipoic acid supplements were measurable as well. Alpha-lipoic acid supplement in obesity treatment: A systematic review and meta-analysis of clinical trials. Alpha lipoic acid (ALA) is a fatty acid which is often referred to as the ‘universal antioxidant'. Current Evidence to Propose Different Food Supplements for Weight Loss: A Comprehensive Review. Alpha-Lipoic-Acid-300 (alpha-lipoic acid) for Dietary Supplementation: “AlA has stoped the tingling in my lower legs. Lipoic acid (often called α-lipoic acid), also known as thioctic acid, is a naturally occurring compound that is also synthesized by humans. Ninety-seven overweight or obese women were put on a weight loss-promoting calorie diet of 30% less than the total energy expenditure. A significant overall mean BMI difference of -0.43 kg/ m2 (confidence interval = -0.82 to -0.03) was found between the ALA and placebo groups. 1. Sharifi-Rad M, Anil Kumar NV, Zucca P, Varoni EM, Dini L, Panzarini E, Rajkovic J, Tsouh Fokou PV, Azzini E, Peluso I, Prakash Mishra A, Nigam M, El Rayess Y, Beyrouthy ME, Polito L, Iriti M, Martins N, Martorell M, Docea AO, Setzer WN, Calina D, Cho WC, Sharifi-Rad J. Epub 2017 Jun 8. In addition, many alternative practitioners contend that alpha-lipoic acid can prevent or treat a multitude of health conditions, including alcoholic liver disease, HIV, Alzheimer's disease, bipolar disorder, cardiac arrhythmia, high blood pressure, rheumatoid arthritis, premature labor, schizoph… As you probably are already aware, weight gain and loss are more complex than a simple calories in/calories out model. Alpha lipoic acid has been proven to help with weight loss and thyroid health, primarily in women. Endogenously synthesized lipoic acid is bound to protein and functions as a cofactor for several important mitochondrial multienzyme complexes. Have you heard about ALA? According to studies, alpha-lipoic acid benefits health by helping to promote weight loss. Mean BMI differences between ALA treatment and placebo, NLM 1997 Sep;46 Suppl 2:S62-6. Carbonelli, et al. Several supplements that may help in weight loss are under research worldwide to help treat overweight and obese people. Several supplements that may help in weight loss are under research worldwide to help treat overweight and obese people. NIH Conclusions: 2020 Jul 2;11:694. doi: 10.3389/fphys.2020.00694.  |  A Randomized Controlled Trial of Long-Term (R)-α-Lipoic Acid Supplementation Promotes Weight Loss in Overweight or Obese Adults without Altering Baseline Elevated Plasma Triglyceride Concentrations. Mean body weight differences between…, Figure 2. 2020 Table IV.15: Evidence of Alpha Lipoic Acid's Weight Loss Effects; Dosage & Details Study Outcomes; 1200 or 1800 mg/day oral alpha lipoic acid in 400-600 mg doses 30 minutes before meals for 20 weeks, combined with a reduced calorie diet (no less than 1200 calories/day, 55-60% carbohydrates).
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